RIS-Enabled Self-Localization: Leveraging Controllable Reflections With Zero Access Points

Reconfigurable intelligent surfaces (RISs) are one of the most promising technological enablers of the next (6th) generation of wireless systems. In this paper, we introduce a novel use-case of the RIS technology in radio localization, which is enabling the user to estimate its own position via transmitting orthogonal frequency-division multiplexing (OFDM) pilots and processing the signal reflected from the RIS. We demonstrate that user localization in this scenario is possible by deriving Cram\ue9r-Rao lower bounds on the positioning error and devising a low-complexity position estimation algorithm. We consider random and directional RIS phase profiles and apply a specific temporal coding to them, such that the reflected signal from the RIS can be separated from the uncontrolled multipath. Finally, we assess the performance of our position estimator for an example system, and show that the proposed algorithm can attain the derived bound at high signal-to-noise ratio values

Near-field Localization with a Reconfigurable Intelligent Surface Acting as Lens

Exploiting wavefront curvature enables localization with limited infrastructure and hardware complexity. With the introduction of reconfigurable intelligent surfaces (RISs), new opportunities arise, in particular when the RIS is functioning as a lens receiver. We investigate the localization of a transmitter using a RIS-based lens in close proximity to a single receive antenna element attached to reception radio frequency chain. We perform a Fisher information analysis, evaluate the impact of different lens configurations, and propose a two-stage localization algorithm. Our results indicate that positional beamforming can lead to better performance when a priori location information is available, while random beamforming is preferred when a priori information is lacking. Our simulation results for a moderate size lens operating at 28 GHz showcased that decimeter-level accuracy can be attained within 3 meters to the lens

Triple‐crystal x‐ray diffraction analysis of reactive ion etched gallium arsenide

This is the published version. Copyright 1994 American Institute of PhysicsThe effect of BCl3 reactive ion etching on the structural perfection of GaAs has been studied with diffuse x‐ray scattering measurementsconducted by high‐resolution triple‐crystal x‐ray diffraction. While using a symmetric 004 diffraction geometry revealed no discernible differences between etched and unetched samples, using the more surface‐sensitive and highly asymmetric 113 reflection revealed that the reactive ion etched samples etched displayed less diffusely scattered intensity than unetched samples, indicating a higher level of structural perfection. Increasing the reaction ion etch bias voltage was found to result in decreased diffuse scattering initially, until an apparent threshold voltage was reached, after which no further structural improvement was observed. Furthermore, we have shown that this reduction in process‐induced surfacestructural damage is not due merely to the removal of residual chemical‐mechanical polishing damage

Forefoot plantar multilobular noninfiltrating angiolipoma: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Soft tissue tumors of the feet are uncommon and there have been very few reports of large series in the literature. These tumors continue to present the clinician with one of the most difficult problems in medicine.</p> <p>Case presentation</p> <p>We present a case of a large multilobular noninfiltrating angiolipoma at the plantar surface of the forefoot. Only three cases occurring at the foot have been previously described. We report this new case due to unusual location of the tumor, the long duration (25 years) of its existence and the unique surgical approach for the tumor excision.</p> <p>Conclusion</p> <p>Surgical excision is the treatment of choice and adjuvant radiotherapy is indicated in select cases.</p

Log-moment estimators of the Nakagami-lognormal distribution

[EN] In this paper, estimators of the Nakagami-lognormal (NL) distribution based on the method of log-moments have been derived and thoroughly analyzed. Unlike maximum likelihood (ML) estimators, the log-moment estimators of the NL distribution are obtained using straightforward equations with a unique solution. Also, their performance has been evaluated using the sample mean, confidence regions and normalized mean square error (NMSE). The NL distribution has been extensively used to model composite small-scale fading and shadowing in wireless communication channels. This distribution is of interest in scenarios where the small-scale fading and the shadowing processes cannot be easily separated such as the vehicular environment.This work has been funded in part by the Programa de Estancias de Movilidad de Profesores e Investigadores en Centros Extranjeros de Ensenanza Superior e Investigacion of the Ministerio de Educacion, Cultura y Deporte, Spain, PR2015-00151 and by the Ministerio de Economia, Industria y Competitividad of the Spanish Government under the national project TEC2017-86779-C2-2-R, through the Agencia Estatal de Investigacion (AEI) and the Fondo Europeo de Desarrollo Regional (FEDER).Reig, J.; Brennan, C.; Rodrigo Peñarrocha, VM.; Rubio Arjona, L. (2019). Log-moment estimators of the Nakagami-lognormal distribution. EURASIP Journal on Wireless Communications and Networking. 1-10. https://doi.org/10.1186/s13638-018-1328-6S110J. M. Ho, G. L. Stüber, in Co-channel interference of microcellular systems on shadowed Nakagami fading channels. Proc. IEEE 43rd Vehicular Technology Conference, 1993 (VTC 93) (IEEESecaucus, 1993), pp. 568–571.A. A. Abu-Dayya, N. C. Beaulieu, Micro- and macrodiversity NCFSK (DPSK) on shadowed Nakagami-fading channels. IEEE Trans. Commun.42(9), 2693–2702 (1994).X. Wang, W. Wang, Z. Bu, Fade statistics for selection diversity in Nakagami-lognormal fading channels. Electron. Lett.42(18), 1046–1047 (2006).D. T. Nguyen, Q. T. Nguyen, S. C. Lam, Analysis and simulation of MRC diversity reception in correlated composite Nakagami-lognormal fading channels. REV J. Electron. Commun.4(1–2), 44–51 (2014).P. Xu, X. Zhou, D. Hu, in Performance evaluations of adaptive modulation over composite Nakagami-lognormal fading channels. 2009 15th Asia-Pacific Conference on Communications (IEEEShanghai, 2009), pp. 467–470.G. C. Alexandropoulos, A. Conti, P. T. Mathiopoulos, in Adaptive M-QAM systems with diversity in correlated Nakagami-m fading and shadowing. IEEE Global Telecommunications Conference (GLOBECOM 2010) (IEEEMiami, 2010), pp. 1–5.Ö. Bulakci, A. B. Saleh, J. Hämäläinen, S. Redana, Performance analysis of relay site planning over composite fading/shadowing channels with cochannel interference. IEEE Trans. Veh. Technol.62(4), 1692–1706 (2013).W. Cheng, Y. Huang, On the performance of adaptive SC/MRC cooperative systems over composite fading channels. Chin. J. Electron.25(3), 533–540 (2016).M. G. Kibria, G. P. Villardi, W. Liao, K. Nguyen, K. Ishizu, F. Kojima, Outage analysis of offloading in heterogeneous networks: Composite fading channels. IEEE Trans. Veh. Technol.66(10), 8990–9004 (2017).K. Cho, J. Lee, C. G. Kang, Stochastic geometry-based coverage and rate analysis under Nakagami & log-normal composite fading channel for downlink cellular networks. IEEE Commun. Lett.21(6), 1437–1440 (2017).R. Singh, M. Rawat, Closed-form distribution and analysis of a combined Nakagami-lognormal shadowing and unshadowing fading channel. J Telecommun. Inf. Technol.4:, 81–87 (2016).J. Reig, L. Rubio, Estimation of the composite fast fading and shadowing distribution using the log-moments in wireless communications. IEEE Trans. Wireless. Commun.12(8), 3672–3681 (2013).S. Atapattu, C. Tellambura, H. Jiang, A mixture gamma distribution to model the SNR of wireless channels. IEEE Trans. Wireless Commun.10(12), 4193–4203 (2011).Q. Wang, H. Lin, P. Kam, Tight bounds and invertible average error probability expressions over composite fading channels. J. Commun. Netw.18(2), 182–189 (2016).J. M. Holtzmann, On using perturbation analysis to do sensitivity analysis: derivatives versus differences. IEEE Trans. Autom. Control. 37(2), 243–247 (1992).H. Suzuki, A statistical model for urban radio propagation. IEEE Trans. Commun.25(7), 673–680 (1977).M. D. Yacoub, The α- μ distribution: a physical fading model for the Stacy distribution. IEEE Trans. Veh. Technol.56(1), 122–124 (2007).P. M. Shankar, Error rates in generalized shadowed fading channels. Wirel. Pers. Commun.28(3), 233–238 (2004).J. -M. Nicolas, Introduction aux statistiques de deuxième espèce: applications des logs-moments et des logs-cumulants à l’analyse des lois d’images radar. Traitement du Signal. 19(3), 139–167 (2002). Translation to English by S. N. Anfinsen.C. Withers, S. Nadarajah, A generalized Suzuki distribution. Wirel. Pers. Commun.62(4), 807–830 (2012).M. Abramowitz, Handbook of Mathematical Functions, with Formulas, Graphs, and Mathematical Tables, 9th edn. (Dover, New York, NY, 1972).M. K. Simon, M. S. Alouini, Digital Communication over Fading Channels, 2nd edn. (Wiley, Hoboken, NY, 2005).Z. Sun, J. Du, in Proc. 10th International Conference, ICIC 2014, ed. by D. -S. Huang, V. Bevilacqua, and P. Premaratne. 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Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Tumor-suppressor activity of RRIG1 in breast cancer

<p>Abstract</p> <p>Background</p> <p>Retinoid receptor-induced gene-1 (RRIG1) is a novel gene that has been lost in several types of human cancers. The aim of this study was to determine whether RRIG1 plays a role in breast cancer, such as in the suppression of breast cancer cell growth and invasion.</p> <p>Methods</p> <p>Immunohistochemistry was used to detect RRIG1 expression in breast tissue specimens. Gene transfection was used to restore or knock down RRIG1 expression in breast cancer cell lines for analysis of cell viability, colony formation, and migration/invasion potential. Reverse-transcription polymerase chain reaction and western blot assays were used to detect the changes in gene expression. The RhoA activation assay was used to assess RRIG1-induced inhibition of RhoA activity.</p> <p>Results</p> <p>The immunohistochemical data showed that <it>RRIG1 </it>expression was reduced in breast cancer tissues compared with normal and atypical hyperplastic breast tissues. <it>RRIG1 </it>expression was inversely correlated with lymph node metastasis of breast cancer but was not associated with the status of hormone receptors, such as estrogen receptor, progesterone receptor, or HER2. Furthermore, restoration of <it>RRIG1 </it>expression inhibited proliferation, colony formation, migration, and invasion of breast cancer cells. Expression of RRIG1 also reduced phosphorylated Erk1/2 and Akt levels; c-Jun, MMP9, and Akt expressions; and RhoA activity. In contrast, knockdown of RRIG1 expression promoted breast cancer cell proliferation, colony formation, migration, and invasion potential.</p> <p>Conclusion</p> <p>The data from the current study indicated that <it>RRIG1 </it>expression was reduced or lost in breast cancer and that restoration of RRIG1 expression suppressed breast cancer cell growth and invasion capacity. Future studies will determine the underlying molecular mechanisms and define RRIG1 as a tumor-suppressor gene in breast cancer.</p

EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

<p>Abstract</p> <p>Background</p> <p>Uveal melanoma (UM) is a rare eye tumor. There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile. Metastatic progression is predominantly originated from class II tumors or from tumors showing loss of an entire chromosome 3 (monosomy 3). We performed detailed <it>EFS </it>(<it>embryonal Fyn-associated substrate</it>) methylation analyses in UM, cultured uveal melanocytes and normal tissues, to explore the role of the differentially methylated <it>EFS </it>promoter region CpG island in tumor classification and metastatic progression.</p> <p>Methods</p> <p><it>EFS </it>methylation was determined by direct sequencing of PCR products from bisulfite-treated DNA or by sequence analysis of individual cloned PCR products. The results were associated with clinical features of tumors and tumor-related death of patients.</p> <p>Results</p> <p>Analysis of 16 UM showed full methylation of the <it>EFS </it>CpG island in 8 (50%), no methylation in 5 (31%) and partial methylation in 3 (19%) tumors. Kaplan-Meier analysis revealed a higher risk of metastatic progression for tumors with <it>EFS </it>methylation (p = 0.02). This correlation was confirmed in an independent set of 24 randomly chosen tumors. Notably, only UM with <it>EFS </it>methylation gave rise to metastases. Real-time quantitative RT-PCR expression analysis revealed a significant inverse correlation of <it>EFS </it>mRNA expression with <it>EFS </it>methylation in UM. We further found that <it>EFS </it>methylation is tissue-specific with full methylation in peripheral blood cells, and no methylation in sperm, cultured primary fibroblasts and fetal muscle, kidney and brain. Adult brain samples, cultured melanocytes from the uveal tract, fetal liver and 3 of 4 buccal swab samples showed partial methylation. <it>EFS </it>methylation always affects both alleles in normal and tumor samples.</p> <p>Conclusions</p> <p>Biallelic <it>EFS </it>methylation is likely to be the result of a site-directed methylation mechanism. Based on partial methylation as observed in cultured melanocytes we hypothesize that there might be methylated and unmethylated precursor cells located in the uveal tract. The <it>EFS </it>methylation of a UM may depend on which type of precursor cell the tumor originated from.</p

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG